AGIOS PHARMACEUTICALS, INC.
AGIONasdaqHealthcare · Pharmaceutical Preparations · DE · SEC filings ↗ · Compare ⊕
View price & chart on Yahoo Finance ↗Financials
SEC XBRL · annual| FY25 | FY24 | FY23 | FY22 | FY21 | FY20 | |
|---|---|---|---|---|---|---|
| Revenue | $54.0M | $36.5M | $26.8M | $14.2M | $0 | $0 |
| Operating income | −$472.1M | −$425.7M | −$391.5M | −$389.0M | −$378.4M | −$335.9M |
| Net income | −$412.8M | $673.7M | −$352.1M | −$231.8M | $1.60B | −$327.4M |
| Total assets | $1.30B | $1.66B | $937.1M | $1.24B | $1.44B | $853.0M |
| Total liabilities | $104.1M | $122.2M | $126.1M | $137.9M | $145.8M | $453.5M |
| Equity | $1.19B | $1.54B | $811.0M | $1.10B | $1.29B | $399.5M |
| EPS (diluted) | $-7.12 | $11.64 | $-6.33 | $-4.23 | $26.55 | $-4.74 |
| Shares out. | 57.3M | 56.2M | 55.3M | 54.6M | 69.6M | 68.5M |
Reported figures from the company's SEC filings (XBRL). Blank where a line item isn't cleanly tagged — never estimated.
Key ratios
from filings · FY2025- Operating margin
- −873.9%
- Net margin
- −764.0%
- Return on equity
- −34.6%
- Return on assets
- −31.8%
- Return on capital (ROCE)
- −38.9%
- Liabilities / assets
- 8.0%
- Debt / equity
- 0.09×
- Book value / share
- $20.82
- Revenue growth (YoY)
- 48.0%
- Net income growth (YoY)
- −161.3%
Computed from the company's own SEC figures — no market price, so these are facts, not a valuation. Book value per share is reported equity ÷ shares; it is not the stock price.
Financial health
forensic scores · FY2025- Altman Z″ (distress)
- 12.52safe
- Accruals / assets
- −3.1%clean
- Piotroski F-Score
- 3/9weak
Altman Z″is a textbook bankruptcy-distress score from book values only (>2.6 safe · 1.1–2.6 grey · <1.1 distress). Accruals = (net income − operating cash flow) ÷ assets; persistently high accruals are an earnings-quality red flag. Beneish M-Scoreis an eight-ratio screen comparing this year with last (M > −1.78 = elevated manipulation-risk screen, not proof). Piotroski F-Scorecounts how many of nine fundamental-health checks pass (shown as passed / applicable; we use operating margin and total liabilities as documented proxies where the exact input isn't XBRL-tagged). Computed from SEC filings — descriptive factors, not advice or a forecast.
Quality score
EDS ScoreOur own multi-factor score from free SEC data — profitability, growth, financial strength, earnings quality, and event/ownership catalysts. No market price and no licensed model: each axis is the share of source-backed checks it passes. Descriptive factors, not advice or a forecast. What these scores mean →
Signs
● 3 warning● 4 good- Operating losses (negative operating margin)
- Reported a net loss
- Negative operating cash flow
- Revenue is growing year-over-year
- Conservative leverage (liabilities < 50% of assets)
- Clean earnings (low accruals)
- Altman Z″ in the safe zone
Derived from the company's own SEC figures (fundamentals, forensic scores, filing discipline) — descriptive factors, not advice or a forecast.
Clinical trials
ClinicalTrials.gov · ongoing · next readout first- Phase 2Active Not Recruitingreadout ~2020-08-20A Study to Determine the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of AG-348 in Adult Participants With Non-transfusion-dependent Thalassemia
- Phase 3Active Not Recruitingreadout ~2023-11-13A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT)
- Phase 3Active Not Recruitingreadout ~2024-04-11A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT)
- Phase 3Active Not Recruitingreadout ~2024-05-03A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period
- Phase 3Active Not Recruitingreadout ~2024-12-13A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Not Regularly Transfused, Followed by a 5-Year Extension Period
- Phase 2/3Active Not Recruitingreadout ~2025-10-30A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)
- Phase 1Active Not Recruitingreadout ~2026-02-11A Study to Determine the Safety and Tolerability of AG-236 and How it is Absorbed, Broken Down, and Eliminated From the Body in Healthy Participants
- Phase 2Active Not Recruitingreadout ~2026-03-17A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)
Interventional studies led by this company. “Readout” is the trial's primary-completion date — an estimate the sponsor reports, not a guarantee.
5%+ owners
SEC Schedule 13D / 13G · last 3 yrs- Armistice Capital, LlcPassive (13G)May 15, 2026
- Lynx1 Capital Management LpPassive (13G)May 6, 2026
- Vanguard Capital Management LlcPassive (13G)Apr 29, 2026
- Vanguard Group IncPassive (13G)Mar 26, 2026
- Farallon Capital Partners, L.P.Passive (13G)Feb 9, 2026
- State Street CorpPassive (13G)Feb 9, 2026
- Bellevue Group AgPassive (13G)Dec 5, 2025
- Paradigm Biocapital Advisors LpPassive (13G)Nov 14, 2025
- Blackrock, Inc.Passive (13G)Jul 17, 2025
- Bb Biotech AgPassive (13G)Jun 13, 2025
Holders who disclosed a 5%+ stake. 13D signals intent to influence or control; 13G is a passive holding. Latest filing per holder — open it for the exact stake.
Short interest
FINRA · bi-monthly| Settlement | Shares short | Days to cover | Δ vs prior |
|---|---|---|---|
| May 15, 2026 | 7.5M | 8.7 | +6.8% |
| Apr 30, 2026 | 7.0M | 4.2 | -1.5% |
| Apr 15, 2026 | 7.1M | 7.0 | +7.2% |
| Mar 31, 2026 | 6.6M | 6.4 | +6.7% |
| Mar 13, 2026 | 6.2M | 8.2 | -0.8% |
Shares sold short as reported to FINRA. Days-to-cover = short shares ÷ average daily volume — higher means more potential squeeze pressure.
Material events
SEC Form 8-K · most recent- Results of operationsApr 29, 2026
- Results of operationsFeb 12, 2026
- Regulation FD disclosureJan 12, 2026
- Results of operationsOct 30, 2025
- Regulation FD disclosureAug 4, 2025
- Results of operationsJul 31, 2025
- Director / officer changeJul 8, 2025
- Director / officer change · Shareholder voteJun 18, 2025
Events the company reported on Form 8-K, labelled by the SEC item code it filed under — its own classification, not our interpretation.
Recent SEC filings
All filings ↗- SCHEDULE 13G/AMay 15, 2026
- SCHEDULE 13GMay 6, 2026
- SCHEDULE 13GApr 29, 2026
- 10-QApr 29, 2026
- 8-KApr 29, 2026
- ARSApr 24, 2026
- DEFA14AApr 24, 2026
- DEF 14AApr 24, 2026
- 4FORM 4Apr 6, 2026
- 4FORM 4Apr 6, 2026
- 4FORM 4Apr 6, 2026
- 4FORM 4Apr 6, 2026
- 4FORM 4Apr 6, 2026
- 4FORM 4Apr 6, 2026
- 144Apr 2, 2026
Event-driven situations (1)
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