Xenon Pharmaceuticals Inc.
XENENasdaqHealthcare · Pharmaceutical Preparations · A1 · SEC filings ↗ · Compare ⊕
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SEC XBRL · annual| FY25 | FY24 | FY23 | FY22 | FY21 | FY20 | |
|---|---|---|---|---|---|---|
| Revenue | $7.5M | $0 | $0 | $9.4M | $18.4M | $32.2M |
| Operating income | −$373.1M | −$279.3M | −$214.1M | −$129.1M | −$79.0M | −$31.3M |
| Net income | −$345.9M | −$234.3M | −$182.4M | −$125.4M | −$78.9M | −$28.8M |
| Total assets | $633.2M | $798.1M | $964.8M | $754.1M | $572.0M | $189.2M |
| Total liabilities | $51.4M | $43.2M | $36.9M | $32.6M | $22.0M | $17.8M |
| Equity | $581.8M | $754.9M | $927.9M | $721.5M | $550.0M | $171.4M |
| EPS (diluted) | $-4.36 | $-3.01 | $-2.73 | $-2.06 | $-1.77 | $-0.81 |
| Shares out. | 76.5M | 75.4M | 63.0M | 51.9M | 35.8M | 35.0M |
Reported figures from the company's SEC filings (XBRL). Blank where a line item isn't cleanly tagged — never estimated.
Key ratios
from filings · FY2025- Operating margin
- −4974.3%
- Net margin
- −4612.1%
- Return on equity
- −59.5%
- Return on assets
- −54.6%
- Return on capital (ROCE)
- −63.1%
- Liabilities / assets
- 8.1%
- Debt / equity
- 0.09×
- Book value / share
- $7.60
- Revenue growth (YoY)
- —
- Net income growth (YoY)
- —
Computed from the company's own SEC figures — no market price, so these are facts, not a valuation. Book value per share is reported equity ÷ shares; it is not the stock price.
Financial health
forensic scores · FY2025- Altman Z″ (distress)
- 6.89safe
- Accruals / assets
- −10.5%clean
- Piotroski F-Score
- 2/8weak
Altman Z″is a textbook bankruptcy-distress score from book values only (>2.6 safe · 1.1–2.6 grey · <1.1 distress). Accruals = (net income − operating cash flow) ÷ assets; persistently high accruals are an earnings-quality red flag. Beneish M-Scoreis an eight-ratio screen comparing this year with last (M > −1.78 = elevated manipulation-risk screen, not proof). Piotroski F-Scorecounts how many of nine fundamental-health checks pass (shown as passed / applicable; we use operating margin and total liabilities as documented proxies where the exact input isn't XBRL-tagged). Computed from SEC filings — descriptive factors, not advice or a forecast.
Quality score
EDS ScoreOur own multi-factor score from free SEC data — profitability, growth, financial strength, earnings quality, and event/ownership catalysts. No market price and no licensed model: each axis is the share of source-backed checks it passes. Descriptive factors, not advice or a forecast.
Signs
● 3 warning● 3 good- Operating losses (negative operating margin)
- Reported a net loss
- Negative operating cash flow
- Conservative leverage (liabilities < 50% of assets)
- Clean earnings (low accruals)
- Altman Z″ in the safe zone
Derived from the company's own SEC figures (fundamentals, forensic scores, filing discipline) — descriptive factors, not advice or a forecast.
Clinical trials
ClinicalTrials.gov · ongoing · next readout first- Phase 2Active Not Recruitingreadout ~2021-09-02A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
- Phase 3Recruitingreadout ~2026-08A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder
- Phase 3Recruitingreadout ~2026-10A Randomized Study of XEN1101 Versus Placebo in Focal-Onset Seizures (X-TOLE3)
- Phase 3Enrolling By Invitationreadout ~2027-01An Open-Label Study of Azetukalner in Major Depressive Disorder
- Phase 3Recruitingreadout ~2027-04A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
- Phase 3Recruitingreadout ~2027-05A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)
- Phase 3Recruitingreadout ~2028-06A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
- Phase 3Enrolling By Invitationreadout ~2029-06An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE)
Interventional studies led by this company. “Readout” is the trial's primary-completion date — an estimate the sponsor reports, not a guarantee.
5%+ owners
SEC Schedule 13D / 13G · last 3 yrs- Janus Henderson Group PlcPassive (13G)May 15, 2026
- Driehaus Capital Management LlcPassive (13G)May 15, 2026
- Avoro Capital Advisors LlcPassive (13G)May 15, 2026
- Wellington Management Group LlpPassive (13G)Feb 10, 2026
- Fmr LlcPassive (13G)Aug 6, 2025
- Blackrock, Inc.Passive (13G)Jul 17, 2025
Holders who disclosed a 5%+ stake. 13D signals intent to influence or control; 13G is a passive holding. Latest filing per holder — open it for the exact stake.
Insider transactions
SEC Form 4 · most recent| Insider | Date | Type | Shares | Price |
|---|---|---|---|---|
| Gannon StevenDirector | May 12, 2026 | Option exercise | 3,500 | $7.38 |
| Kenney Christopher JohnOfficer — Chief Medical Officer | Mar 12, 2026 | Option exercise | 3,750 | — |
| Difabio AndreaOfficer — Chief Legal Officer | Mar 12, 2026 | Option exercise | 3,750 | — |
| Mortimer IanOfficer — PRESIDENT & CEO | Mar 12, 2026 | Option exercise | 12,500 | — |
| Kenney Christopher JohnOfficer — Chief Medical Officer | Mar 9, 2026 | Option exercise | 7,500 | — |
| Difabio AndreaOfficer — Chief Legal Officer | Mar 9, 2026 | Option exercise | 7,500 | — |
| Mortimer IanOfficer — PRESIDENT & CEO | Mar 9, 2026 | Option exercise | 75,000 | $8.40 |
| Mortimer IanOfficer — PRESIDENT & CEO | Jan 2, 2026 | Option exercise | 40,000 | $7.49 |
Headline trade per Form 4 (officers, directors, 10%+ owners). Buy/sell read from the filing's structured data — blank where a field isn't cleanly tagged.
Short interest
FINRA · bi-monthly| Settlement | Shares short | Days to cover | Δ vs prior |
|---|---|---|---|
| May 15, 2026 | 3.8M | 4.0 | -7.6% |
| Apr 30, 2026 | 4.1M | 4.6 | -14.5% |
| Apr 15, 2026 | 4.9M | 5.4 | +0.1% |
| Mar 31, 2026 | 4.9M | 3.5 | -11.0% |
| Mar 13, 2026 | 5.5M | 1.7 | -1.5% |
Shares sold short as reported to FINRA. Days-to-cover = short shares ÷ average daily volume — higher means more potential squeeze pressure.
Material events
SEC Form 8-K · most recent- Results of operations · Regulation FD disclosureMay 7, 2026
- Director / officer changeApr 13, 2026
- Other material eventMar 13, 2026
- Entered a material agreement · Other material eventMar 12, 2026
- Regulation FD disclosureMar 9, 2026
- Other material eventFeb 27, 2026
- Results of operations · Regulation FD disclosureFeb 26, 2026
- Director / officer changeDec 1, 2025
Events the company reported on Form 8-K, labelled by the SEC item code it filed under — its own classification, not our interpretation.
Recent SEC filings
All filings ↗- SCHEDULE 13G/AMay 15, 2026
- SCHEDULE 13G/AMay 15, 2026
- SCHEDULE 13G/AMay 15, 2026
- 4May 13, 2026
- 10-QMay 7, 2026
- 8-KMay 7, 2026
- ARSApr 22, 2026
- DEFA14AApr 22, 2026
- DEF 14AApr 22, 2026
- S-8Apr 13, 2026
- 8-KApr 13, 2026
- 4Mar 13, 2026
- 4Mar 13, 2026
- 4Mar 13, 2026
- 144Mar 13, 2026
Event-driven situations (1)
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