Tyra Biosciences, Inc.
TYRANasdaqHealthcare · Pharmaceutical Preparations · DE · SEC filings ↗ · Compare ⊕
View price & chart on Yahoo Finance ↗Financials
SEC XBRL · annual| FY25 | FY24 | FY23 | FY22 | FY21 | FY20 | |
|---|---|---|---|---|---|---|
| Revenue | — | — | — | — | — | — |
| Operating income | −$132.8M | −$104.2M | −$79.9M | −$58.9M | −$26.3M | −$9.3M |
| Net income | −$119.9M | −$86.5M | −$69.1M | −$55.3M | −$26.3M | −$9.3M |
| Total assets | $282.6M | $363.6M | $225.9M | $266.2M | $306.7M | $16.0M |
| Total liabilities | $23.4M | $20.4M | $21.6M | $8.4M | $5.0M | $2.0M |
| Equity | $259.2M | $343.2M | $204.3M | $257.8M | $301.7M | −$13.6M |
| EPS (diluted) | $-2.01 | $-1.51 | $-1.62 | $-1.32 | $-1.91 | — |
| Shares out. | 53.1M | 52.5M | 42.4M | 41.6M | 41.4M | 1.8M |
Reported figures from the company's SEC filings (XBRL). Blank where a line item isn't cleanly tagged — never estimated.
Key ratios
from filings · FY2025- Operating margin
- —
- Net margin
- —
- Return on equity
- −46.3%
- Return on assets
- −42.4%
- Return on capital (ROCE)
- −50.2%
- Liabilities / assets
- 8.3%
- Debt / equity
- 0.09×
- Book value / share
- $4.88
- Revenue growth (YoY)
- —
- Net income growth (YoY)
- —
Computed from the company's own SEC figures — no market price, so these are facts, not a valuation. Book value per share is reported equity ÷ shares; it is not the stock price.
Financial health
forensic scores · FY2025- Altman Z″ (distress)
- 9.92safe
- Accruals / assets
- −8.8%clean
- Piotroski F-Score
- 1/7weak
Altman Z″is a textbook bankruptcy-distress score from book values only (>2.6 safe · 1.1–2.6 grey · <1.1 distress). Accruals = (net income − operating cash flow) ÷ assets; persistently high accruals are an earnings-quality red flag. Beneish M-Scoreis an eight-ratio screen comparing this year with last (M > −1.78 = elevated manipulation-risk screen, not proof). Piotroski F-Scorecounts how many of nine fundamental-health checks pass (shown as passed / applicable; we use operating margin and total liabilities as documented proxies where the exact input isn't XBRL-tagged). Computed from SEC filings — descriptive factors, not advice or a forecast.
Quality score
EDS ScoreOur own multi-factor score from free SEC data — profitability, growth, financial strength, earnings quality, and event/ownership catalysts. No market price and no licensed model: each axis is the share of source-backed checks it passes. Descriptive factors, not advice or a forecast.
Signs
● 1 warning● 3 good- Negative operating cash flow
- Conservative leverage (liabilities < 50% of assets)
- Clean earnings (low accruals)
- Altman Z″ in the safe zone
Derived from the company's own SEC figures (fundamentals, forensic scores, filing discipline) — descriptive factors, not advice or a forecast.
Clinical trials
ClinicalTrials.gov · ongoing · next readout first- Phase 1Active Not Recruitingreadout ~2025-05A Relative Bioavailability and Food Effect Study of TYRA-300-B01 Capsule and Tablet Formulations in Healthy Adult Participants
- Phase 1Recruitingreadout ~2026-09Safety and Anti-Tumor Activity of TYRA-200 in Advanced Cholangiocarcinoma With Activating FGFR2 Gene Alterations
- Phase 1/2Active Not Recruitingreadout ~2026-11Safety and Preliminary Anti-Tumor Activity of TYRA-300 in Advanced Urothelial Carcinoma and Other Solid Tumors With FGFR3 Gene Alterations
- Phase 1Recruitingreadout ~2028-01Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
- Phase 2Recruitingreadout ~2028-02Efficacy and Safety of TYRA-300 in Participants With FGFR3 Altered Low Grade, Intermediate Risk Non-Muscle Invasive Bladder Cancer
- Phase 2Recruitingreadout ~2030-01A Study of TYRA-300 in Children With Achondroplasia: BEACH301
- Phase 2Recruitingreadout ~2030-10Phase 2A/B Efficacy and Safety of Dabogratinib in Participants With Low Grade Upper Tract Urothelial Carcinoma
Interventional studies led by this company. “Readout” is the trial's primary-completion date — an estimate the sponsor reports, not a guarantee.
Short interest
FINRA · bi-monthly| Settlement | Shares short | Days to cover | Δ vs prior |
|---|---|---|---|
| May 15, 2026 | 8.1M | 12.7 | +4.6% |
| Apr 30, 2026 | 7.7M | 6.7 | -0.0% |
| Apr 15, 2026 | 7.7M | 7.6 | -6.7% |
| Mar 31, 2026 | 8.3M | 7.9 | +20.6% |
| Mar 13, 2026 | 6.9M | 4.1 | +20.9% |
Shares sold short as reported to FINRA. Days-to-cover = short shares ÷ average daily volume — higher means more potential squeeze pressure.
Material events
SEC Form 8-K · most recent- Results of operationsMay 13, 2026
- Director / officer changeApr 17, 2026
- Director / officer changeApr 2, 2026
- Other material eventMar 4, 2026
- Results of operationsMar 2, 2026
- Director / officer changeDec 1, 2025
- Results of operationsNov 5, 2025
- Other material eventAug 22, 2025
Events the company reported on Form 8-K, labelled by the SEC item code it filed under — its own classification, not our interpretation.
Recent SEC filings
All filings ↗- 4Jun 1, 2026
- 4Jun 1, 2026
- 4Jun 1, 2026
- 4Jun 1, 2026
- 4Jun 1, 2026
- 4Jun 1, 2026
- 4Jun 1, 2026
- 144Jun 1, 2026
- SCHEDULE 13G/AMay 15, 2026
- SCHEDULE 13G/AMay 15, 2026
- SCHEDULE 13G/AMay 14, 2026
- 10-QMay 13, 2026
- 8-KMay 13, 2026
- 144May 12, 2026
- SCHEDULE 13G/AMay 12, 2026
Event-driven situations (2)
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