Sionna Therapeutics, Inc.
SIONNasdaqHealthcare · Pharmaceutical Preparations · DE · SEC filings ↗ · Compare ⊕
View price & chart on Yahoo Finance ↗Financials
SEC XBRL · annual| FY25 | FY24 | |
|---|---|---|
| Revenue | — | — |
| Operating income | −$89.0M | −$70.6M |
| Net income | −$75.3M | −$61.7M |
| Total assets | $326.0M | $185.8M |
| Total liabilities | $19.1M | $19.1M |
| Equity | $306.8M | −$163.7M |
| EPS (diluted) | $-1.88 | $-15.99 |
| Shares out. | 44.7M | 4.7M |
Reported figures from the company's SEC filings (XBRL). Blank where a line item isn't cleanly tagged — never estimated.
Key ratios
from filings · FY2025- Operating margin
- —
- Net margin
- —
- Return on equity
- −24.5%
- Return on assets
- −23.1%
- Return on capital (ROCE)
- −28.3%
- Liabilities / assets
- 5.9%
- Debt / equity
- 0.06×
- Book value / share
- $6.86
- Revenue growth (YoY)
- —
- Net income growth (YoY)
- —
Computed from the company's own SEC figures — no market price, so these are facts, not a valuation. Book value per share is reported equity ÷ shares; it is not the stock price.
Financial health
forensic scores · FY2025- Altman Z″ (distress)
- 17.07safe
- Accruals / assets
- −2.8%clean
- Piotroski F-Score
- 4/7mixed
Altman Z″is a textbook bankruptcy-distress score from book values only (>2.6 safe · 1.1–2.6 grey · <1.1 distress). Accruals = (net income − operating cash flow) ÷ assets; persistently high accruals are an earnings-quality red flag. Beneish M-Scoreis an eight-ratio screen comparing this year with last (M > −1.78 = elevated manipulation-risk screen, not proof). Piotroski F-Scorecounts how many of nine fundamental-health checks pass (shown as passed / applicable; we use operating margin and total liabilities as documented proxies where the exact input isn't XBRL-tagged). Computed from SEC filings — descriptive factors, not advice or a forecast.
Quality score
EDS ScoreOur own multi-factor score from free SEC data — profitability, growth, financial strength, earnings quality, and event/ownership catalysts. No market price and no licensed model: each axis is the share of source-backed checks it passes. Descriptive factors, not advice or a forecast.
Signs
● 1 warning● 3 good- Negative operating cash flow
- Conservative leverage (liabilities < 50% of assets)
- Clean earnings (low accruals)
- Altman Z″ in the safe zone
Derived from the company's own SEC figures (fundamentals, forensic scores, filing discipline) — descriptive factors, not advice or a forecast.
Clinical trials
ClinicalTrials.gov · ongoing · next readout first- Phase 1Recruitingreadout ~2026-06Safety, Tolerability, and Pharmacokinetics of Multiple Dose Combinations of SION-451 and Complementary Modulators SION-2222 and SION-109 in Healthy Participants.
- Phase 2Active Not Recruitingreadout ~2026-07Proof-of-concept Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of SION-719 When Added to Trikafta
Interventional studies led by this company. “Readout” is the trial's primary-completion date — an estimate the sponsor reports, not a guarantee.
5%+ owners
SEC Schedule 13D / 13G · last 3 yrs- Viking Global Investors LpPassive (13G)May 15, 2026
- Qatar Investment AuthorityPassive (13G)May 12, 2026
- Orbimed Advisors LlcActivist (13D)Apr 20, 2026
- Ra Capital Management, L.P.Activist (13D)Nov 7, 2025
- Jpmorgan Chase & CoPassive (13G)Oct 31, 2025
- Atlas Venture Fund Xi, L.P.Activist (13D)Oct 20, 2025
- Tpg Gp A, LlcActivist (13D)Feb 18, 2025
- Enavate Sciences Gp, LlcActivist (13D)Feb 18, 2025
Holders who disclosed a 5%+ stake. 13D signals intent to influence or control; 13G is a passive holding. Latest filing per holder — open it for the exact stake.
Short interest
FINRA · bi-monthly| Settlement | Shares short | Days to cover | Δ vs prior |
|---|---|---|---|
| May 15, 2026 | 4.7M | 11.3 | +12.1% |
| Apr 30, 2026 | 4.2M | 9.3 | +11.3% |
| Apr 15, 2026 | 3.8M | 8.5 | +1.1% |
| Mar 31, 2026 | 3.8M | 11.3 | +6.0% |
| Mar 13, 2026 | 3.5M | 12.3 | +5.8% |
Shares sold short as reported to FINRA. Days-to-cover = short shares ÷ average daily volume — higher means more potential squeeze pressure.
Material events
SEC Form 8-K · most recent- Results of operationsMay 12, 2026
- Results of operationsMar 2, 2026
- Results of operationsNov 5, 2025
- Results of operationsAug 11, 2025
- Shareholder voteJun 13, 2025
- Regulation FD disclosureJun 4, 2025
- Results of operationsMay 12, 2025
- Results of operationsMar 20, 2025
Events the company reported on Form 8-K, labelled by the SEC item code it filed under — its own classification, not our interpretation.
Recent SEC filings
All filings ↗Event-driven situations (2)
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