ARROWHEAD PHARMACEUTICALS, INC.
ARWRNasdaqHealthcare · Pharmaceutical Preparations · DE · SEC filings ↗ · Compare ⊕
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SEC XBRL · annual| FY25 | FY24 | FY23 | FY22 | FY21 | FY20 | |
|---|---|---|---|---|---|---|
| Revenue | $829.4M | $3.6M | $240.7M | $243.2M | $138.3M | $88.0M |
| Operating income | $98.3M | −$601.1M | −$205.0M | −$178.5M | −$149.0M | −$93.2M |
| Net income | −$1.6M | −$599.5M | −$205.3M | −$176.1M | −$140.8M | −$84.6M |
| Total assets | $1.39B | $1.14B | $765.6M | $691.9M | $710.1M | $522.5M |
| Total liabilities | — | — | — | — | — | — |
| Equity | $466.1M | $185.4M | $271.3M | $398.5M | $408.8M | $461.8M |
| EPS (diluted) | $-0.01 | $-5.00 | $-1.92 | $-1.67 | $-1.36 | $-0.84 |
| Shares out. | 135.8M | 124.4M | 107.4M | 106.0M | 104.5M | 102.8M |
Reported figures from the company's SEC filings (XBRL). Blank where a line item isn't cleanly tagged — never estimated.
Key ratios
from filings · FY2025- Operating margin
- 11.9%
- Net margin
- −0.2%
- Return on equity
- −0.3%
- Return on assets
- −0.1%
- Return on capital (ROCE)
- 8.3%
- Liabilities / assets
- —
- Debt / equity
- —
- Book value / share
- $3.43
- Revenue growth (YoY)
- 23258.2%
- Net income growth (YoY)
- —
Computed from the company's own SEC figures — no market price, so these are facts, not a valuation. Book value per share is reported equity ÷ shares; it is not the stock price.
Financial health
forensic scores · FY2025- Accruals / assets
- −13.1%clean
- Piotroski F-Score
- 5/8mixed
Altman Z″is a textbook bankruptcy-distress score from book values only (>2.6 safe · 1.1–2.6 grey · <1.1 distress). Accruals = (net income − operating cash flow) ÷ assets; persistently high accruals are an earnings-quality red flag. Beneish M-Scoreis an eight-ratio screen comparing this year with last (M > −1.78 = elevated manipulation-risk screen, not proof). Piotroski F-Scorecounts how many of nine fundamental-health checks pass (shown as passed / applicable; we use operating margin and total liabilities as documented proxies where the exact input isn't XBRL-tagged). Computed from SEC filings — descriptive factors, not advice or a forecast.
Quality score
EDS ScoreOur own multi-factor score from free SEC data — profitability, growth, financial strength, earnings quality, and event/ownership catalysts. No market price and no licensed model: each axis is the share of source-backed checks it passes. Descriptive factors, not advice or a forecast.
Signs
● 1 warning● 4 good- Reported a net loss
- Operating margin is positive
- Revenue is growing year-over-year
- Positive operating cash flow
- Clean earnings (low accruals)
Derived from the company's own SEC figures (fundamentals, forensic scores, filing discipline) — descriptive factors, not advice or a forecast.
FDA-approved drugs
openFDA · most recent- REDEMPLONov 18, 2025
Clinical trials
ClinicalTrials.gov · ongoing · next readout first- Phase 3Active Not Recruitingreadout ~2024-04-29Study of ARO-APOC3 (Plozasiran) in Adults With Familial Chylomicronemia Syndrome (FCS)
- Phase 3Active Not Recruitingreadout ~2026-05Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia
- Phase 3Active Not Recruitingreadout ~2026-06Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia
- Phase 1/2Recruitingreadout ~2026-06Study of ARO-DIMERPA in Adult Participants With Mixed Hyperlipidemia
- Phase 3Active Not Recruitingreadout ~2026-06Study of Plozasiran in Adults With Severe Hypertriglyceridemia
- Phase 1Recruitingreadout ~2026-08-07Azithromycin Before Induction
- Phase 1/2Recruitingreadout ~2026-10A First-In-Human Study of ARO-ALK7 in Adults With Obesity With and Without Type 2 Diabetes Mellitus
- Phase 1Recruitingreadout ~2026-12Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2
Interventional studies led by this company. “Readout” is the trial's primary-completion date — an estimate the sponsor reports, not a guarantee.
5%+ owners
SEC Schedule 13D / 13G · last 3 yrs- Fmr LlcPassive (13G)May 6, 2026
- Vanguard Capital Management LlcPassive (13G)Apr 29, 2026
- Vanguard Portfolio Management LlcPassive (13G)Apr 28, 2026
- Blackrock, Inc.Passive (13G)Apr 24, 2026
- Vanguard Group IncPassive (13G)Mar 26, 2026
- Sarepta Therapeutics, Inc.Activist (13D)Aug 15, 2025
- Avoro Capital Advisors LlcPassive (13G)Aug 14, 2025
- State Street CorpPassive (13G)Aug 11, 2025
Holders who disclosed a 5%+ stake. 13D signals intent to influence or control; 13G is a passive holding. Latest filing per holder — open it for the exact stake.
Insider transactions
SEC Form 4 · most recent| Insider | Date | Type | Shares | Price |
|---|---|---|---|---|
| Apel Daniel JosephOfficer — Chief Financial Officer | Jan 6, 2026 | Grant | 75,000 | $0.00 |
| O'Brien PatrickOfficer — COO | Jan 6, 2026 | Gift | 540 | $0.00 |
| O'Brien PatrickOfficer — COO | Dec 31, 2025 | Gift | 560 | $0.00 |
Headline trade per Form 4 (officers, directors, 10%+ owners). Buy/sell read from the filing's structured data — blank where a field isn't cleanly tagged.
Short interest
FINRA · bi-monthly| Settlement | Shares short | Days to cover | Δ vs prior |
|---|---|---|---|
| May 15, 2026 | 12.9M | 7.0 | -0.1% |
| Apr 30, 2026 | 12.9M | 6.7 | +7.7% |
| Apr 15, 2026 | 12.0M | 7.7 | -7.6% |
| Mar 31, 2026 | 13.0M | 5.3 | +13.8% |
| Mar 13, 2026 | 11.4M | 4.3 | +2.6% |
Shares sold short as reported to FINRA. Days-to-cover = short shares ÷ average daily volume — higher means more potential squeeze pressure.
Material events
SEC Form 8-K · most recent- Results of operationsMay 7, 2026
- Shareholder voteMar 20, 2026
- Results of operationsFeb 5, 2026
- Entered a material agreement · New financial obligationJan 12, 2026
- Entered a material agreement · Other material eventJan 9, 2026
- Regulation FD disclosure · Other material eventJan 6, 2026
- Results of operationsNov 25, 2025
- Other material eventNov 18, 2025
Events the company reported on Form 8-K, labelled by the SEC item code it filed under — its own classification, not our interpretation.
Recent SEC filings
All filings ↗- 144/AMay 19, 2026
- 144/AMay 19, 2026
- 144/AMay 19, 2026
- 4FORM 4May 14, 2026
- 144May 12, 2026
- S-8May 7, 2026
- 10-QMay 7, 2026
- 8-KMay 7, 2026
- SCHEDULE 13GMay 6, 2026
- SCHEDULE 13GApr 29, 2026
- SCHEDULE 13GApr 28, 2026
- 4FORM 4Apr 24, 2026
- 4FORM 4Apr 24, 2026
- SCHEDULE 13G/AApr 24, 2026
- 144Apr 23, 2026